2nd International Symposium On Microgenomics – Attend the Scientific Presentation of Prof. Paterlini-Bréchot, CSO of Rarecells Diagnostics – 2 June 2016 at 12:40

As invited speaker, Prof. Paterlini-Bréchot will attende the session 1 “Sampling Methods” with a presentation on the 2nd of June 2016 at 12:40 am entitled “Technical insights into highly sensitive isolation and molecular characterization of circulating tumor cells for early detection of tumor invasion

Abstract:

Introduction

An unsolved technical issue in the Circulating Tumor Cells (CTC) field is how to obtain highly sensitive and unbiased collection of these fragile and heterogeneous cells, in both live and fixed form, for their molecular study when they are extremely rare, thus at the beginning of the invasion process.

Material and Methods

We have explored the potential of ISET® (Isolation by SizE of Tumor Cells), an open platform developed for marker-independent isolation of tumor cells from blood, to collect intact fixed and live cancer cells by using spiking analyses with extremely low numbers of fluorescent cultured cells. Then we have assessed the feasibility of Next Generation Sequencing (NGS) analyses targeted to single cells enriched by ISET using the hotspot cancer panel v2 on the Ion Torrent platform. This panel can detect 6893 possible COSMIC mutations over 50 oncogenes and tumor suppressor genes.

Results and Discussion

Our results consistently show the feasibility of isolating fixed and live tumor cells with a sensitivity close to one cancer cell per 10 mL of blood. We also demonstrate the feasibility of NGS analysis of single live cells enriched by ISET® with Ion Torrent Plateform. Our data provide evidence that the analysis of three single cells enriched by ISET® is sufficient to reliably identify the mutated allele frequency in the target cell population.

Conclusions

These technical improvements should help the study of circulating cancer cells at the early steps of tumor invasion.”

 

Further information here: http://www6.inra.fr/microgenomics-2016

Event’s Program here: http://www6.inra.fr/microgenomics-2016/Final-Scientific-Program

15th International Conference On Preimplantation Genetic Diagnosis – Attend the Scientific Presentation of Prof. Paterlini-Bréchot, CSO of Rarecells Diagnostics – 9 May 2016 at 09:00

As invited speaker, Prof. Paterlini-Bréchot will give a presentation on the 9th of May 2016 at 09:00 am entitled “NIPT of foetal aneuploidies: a dream become reality

Abstract:

“Next Generation Sequencing of cell-free fetal DNA from maternal plasma, also known as non-invasive prenatal testing (NIPT), has enabled accurate prenatal diagnosis of aneuploidies, in particular trisomy 21, and other prevalent aneuploidies (e.g., trisomy 18, trisomy 13) gaining clinical acceptance, as it significantly reduces the necessity of invasive diagnostic procedures. However, these aneuploidies have been estimated to account for approximately two-thirds of prenatal abnormal karyotypes.

Although NIPT technology is evolving, current available tests provide no -or limited- information about other less common chromosome anomalies, and monogenic disorders that can be identified by invasive diagnostics.

Circulating fetal erythroid cells would be the ideal target to develop an alternative non invasive prenatal diagnostics. However, they are very inconsistently found because of their short life and frequent apoptosis.

Our work has explored the potential of Circulating Fetal Trophoblastic Cells (CFTC) collected non-invasively from maternal blood and from maternal cervix to perform genetic diagnosis of monogenic disorders, using Cystic Fibrosis (CF) and Spinal Muscular Atrophy (SMA) as models. […]”

Further information here: http://pgdiscongress2016.com/

Event’s Program here: http://pgdiscongress2016.com/Program.aspx

Prague Spring Symposium 2016 – Attend the Scientific Presentation of Prof. Paterlini-Bréchot, CSO Rarecells Diagnostics

As invited speaker, Prof. Paterlini-Brechot will give a presentation on the 29th of April 2016 at 15:30 entitled “ISET Method for Enrichement and Detection of Circulating Rare Cells and its Clinical Application”.
Further information here: http://www.slg.cz/2016/prague-spring-symposium

Event’s Program here: http://www.slg.cz/system/files/prague-spring-symposium-2016-program_0.pdf

 

3rd Annual European conference “Advances in Prenatal Molecular Diagnostics” 4-6 April, Lisbon

Attend the Scientific Presentation of Prof. Paterlini-Bréchot, CSO Rarecells Diagnostics – 06 April 2016 at 8:45

As invited speaker and chairperson, the Prof. Patrizia Paterlini-Bréchot will attend the  DAY 3 SESSION : FETAL CELL ISOLATION AND ANALYSYS on April 06th at 8:45 with a lecture entitled: “Advances in the Use of Trophoblastic Cells for Prenatal Non-Invasive Diagnostics of Genetic Disorders.

Abstract:
“Non-Invasive Prenatal Diagnosis is technically bound to the challenge of analyzing rare fetal DNA sequences, extracted from blood along with maternal DNA sequences, or rare trophoblastic cells, extracted from blood or cervical samples along with maternal cells. Our results show that ISET allows the consistent recovery of trophoblastic cells from blood and cervical samples and the feasibility of using the trophoblast-derived fetal DNA for noninvasive prenatal diagnosis (NIPND). The advantages and limitations of using fetal cells versus those of using cell-free DNA for developing non-invasive prenatal diagnostic tests will also be discussed.”

Further information and agenda here: http://www.moleculardxeurope.com/Prenatal-Dx/

TRICON 2016, 6-11 Mars 2016, San Francisco

 

RARECELLS Diagnostics and Cambridge Healthtech Institute (CHI) invite you to attend the 23rd International Molecular Med TRI-CON 2016 taking place on March 6-11, 2016 at the Moscone North Convention Center in San Francisco, CA. We are proud to be a Corporate Support Sponsor of this event.

Please find below our leaflet:

Journée nationale de l’innovation en santé – 24 January 2016

 Attend the conference of Prof. Paterlini-Bréchot

As invited speaker, Prof. Patrizia Paterlini-Bréchot, creator of ISET test, will attend the conference “Les innovateurs de la santé” 24th January 2016 at 14:00

Further information here: http://www.cite-sciences.fr/fr/au-programme/lieux-ressources/cite-de-la-sante/au-programme/cycle-innovation-sante/

TEDx Toulouse

Attend the presentation of Prof. Paterlini-Bréchot, CSO Rarecells Diagnostics on October, 17th 2015

As invited speaker, Prof. Patrizia Paterlini-Bréchot, creator of ISET test, will attend the TEDxToulouse conference on Novembre 17th 2015 on the topic “Comment prendre de vitesse le cancer pour le vaincre”.

Update: Find below the video of the lecture:

FuturaPolis 2015, 28 Novembre 2015

Attend the participation of Prof. Paterlini-Bréchot

As invited speaker, Prof. Patrizia Paterlini-Bréchot, creator of ISET test, will attend the debate “Découverte : la fin du cancer ?” 28th Novembre 2015 at 14:40

Further information here: http://www.futurapolis.com/programme2015/

3rd Annual conference “Advances in Prenatal Molecular Diagnostics”, November 16-18, Boston

Trends & Implications in a rapidly changing landscape

Attend the Scientific Presentation of Prof. Paterlini-Bréchot, CSO Rarecells Diagnostics – 18 November 2015 at 8:35

As invited speaker, the Prof. Patrizia Paterlini-Bréchot will attend the  SESSION 3: THE PROMISE AND PROSPECTS FOR FETAL CELLS FROM MATERNAL BLOOD on November 18th at 8:35 with a lecture entitled: TARGETING PURE FETAL DNA FROM CIRCULATING TROPHOBLASTIC CELLS FOR THE DEVELOPMENT OF PRENATAL NON-INVASIVE DIAGNOSTICS OF GENETIC DISORDERS AND TECHNICAL ASPECTS.

Further information and agenda here: http://www.healthtech.com/prenatal-diagnostics/#Day3

7th International Conference on Tumor Microenvironment

Progression, Therapy & Prevention – Attend the Scientific Presentation of Prof. Paterlini-Bréchot, CSO Rarecells Diagnostics – 14 Octobre 2015 17h15

As invited speaker, Prof. Patrizia Paterlini-Bréchot will attend the PLENARY SESSION 6: Metastasis & the Metastatic Microenvironment (I) on October 14th at 17h15 with a lecture entitled: CIRCULATING TUMOR CELLS AND TUMOR MICROENVIRONMENT.

Further information here: http://cancermicroenvironment.tau.ac.il/2015-tel-aviv-israel.html