Cancer is the second cause of death, accounting for nearly 9 million deaths in 2017 all over the world. In 2019, 1,762,450 new cancer cases and 606,880 cancer deaths are projected to occur in the United States. It is estimated that metastasis is the primary cause of 90% of all cancer-related deaths. Circulating Tumor Cells (CTCs) detection and analysis are the foundation of non-invasive tests that can be used repeatedly to support early detection, prognosis, theranostic and personal response monitoring to treatment.