NGS & Clinical Diagnostics Congress 2017 – Attend the Scientific Presentation of Prof. Paterlini-Bréchot, Scientific Advisor of Rarecells Diagnostics – November the 9th, 2017 at 5:00 pm

As invited speaker, Prof. Paterlini-Bréchot will attend the NGS & Clinical Diagnostics Congress with a presentation on the 9th of November 2017 at 5:00 pm entitled “Clinical Impact Of Molecular Analysis Of Circulating Rare Cells“.

Abstract:

  • Circulating rare cells represent a new field of medicine with potential clinical impact
  • Their immuno-molecular characterization is meant to improve personalized medicine
  • Technical challenges have limited this field in the past but recent developments open new pathways for their analys

Further information here: https://www.nextgenerationsequencing-congress.com/

FUTURAPOLIS SANTE 2017: Round-Table "Ces deux femmes veulent devance le cancer" – Attend the participation of Prof. Paterlini-Bréchot, Scientific Advisor of Rarecells Diagnostics – October 14th, 2017 at 12:20 pm

As invited speaker, Prof. Paterlini-Bréchot will attend the FuturaPolis 2017 in Montpellier with a round-table conference on the14th of October 2017 at 12:20 pm entitled “Ces deux femmes veulent devance le cancer”.

Further information here: http://www.futurapolis-sante.com/sessions/ces-deux-femmes-veulent-devancer-le-cancer/

WOMEN’S FORUM ROME 2017: Round-Table “The Value of excellence and research for a better future” – Attend the participation of Prof. Paterlini-Bréchot, Scientific Advisor of Rarecells Diagnostics – June 26th, 2017 at 09:10 am

As invited speaker, Prof. Paterlini-Bréchot will participate in the round-table entitled “The Value of excellence and research for a better future“.

Further information here: http://www.womens-forum.com/meetings/rome-2017

Molecular Diagnostics Europe 2017 Congress – Attend the Scientific Presentation of Prof. Paterlini-Bréchot, Scientific Advisor of Rarecells Diagnostics – April the 12th, 2017 at 9:05 am

As invited speaker, Prof. Paterlini-Bréchot will attend the Molecular Diagnostics Europe 2017 Congress with a presentation on the 12th of April 2017 at 09:05 am entitled “Updated Results for Isolation and Genetic Characterization of Trophoblastic Cells for Prenatal Diagnosis of Genetic Diseases”

Abstract:
The development of a non-invasive alternative to the invasive approaches for prenatal diagnosis of genetic diseases requires the use of fetal DNA non-mixed with maternal DNA, thus the availability of cells carrying the fetal DNA. We have developed ISET, allowing the consistent recovery of trophoblastic cells from blood and cervical samples, and have developed methods for the extensive genetic analyses of the collected cells. We will present results of the use of trophoblastic cells isolated by ISET for non-invasive prenatal diagnosis of trisomy 21 and monogenic disorders and discuss the technical issues involved in bringing to the market this new approach.

Further information here: http://www.moleculardxeurope.com/Prenatal-Dx/

Tricon 2017 – Attend the Scientific Presentation of Prof. Paterlini-Bréchot, Scientific Advisor of Rarecells Diagnostics – February the 21st, 2017 at 12:25 pm

As invited speaker, Prof. Paterlini-Bréchot will attend the TRICON 2017 with a presentation on the 21st of February 2017 at 12:25 am entitled “Highly Sensitive Isolation and Molecular Characterization of CTC for Early Detection of Tumor Invasion”.

Abstract:

ISET allows to isolate fixed and live tumor cells with sensitivity down to one per 10 mL of blood. We show NGS analyses of single cells enriched by ISET® and of tumor cells before and after isolation and culture.

Further information here: http://www.triconference.com/Circulating-Tumor-Cells/

Oncotrans 2017 Congress – Attend the Scientific Presentation of Prof. Paterlini-Bréchot, Scientific Advisor of Rarecells Diagnostics – February the 2nd, 2017 at 3:40 pm

As invited speaker, Prof. Paterlini-Bréchot will attend the Oncotrans 2017 Congress with a presentation on the 2nd of February 2017 at 15:40 am entitled “Technical Insights into highly sensitive isolation and molecular characterization of circulating tumor cells for early detection of tumor invasion.”

Introduction:
An unsolved technical issue in the Circulating Tumor Cells (CTC) field is how to obtain highly sensitive and unbiased collection of these fragile and heterogeneous cells, in both live and fixed form, for their molecular study when they are extremely rare, thus at the beginning of the invasion process.

Material and Methods
We have explored the potential of ISET® (Isolation by SizE of Tumor Cells), an open platform developed for marker-independent isolation of tumor cells from blood, to collect intact fixed and live cancer cells by using spiking analyses with extremely low numbers of fluorescent cultured cells. Then we have assessed the feasibility of Next Generation Sequencing (NGS) analyses targeted to single cells enriched by ISET using the hotspot cancer panel v2 on the Ion Torrent platform. This panel can detect 6893 possible COSMIC mutations over 50 oncogenes and tumor suppressor genes.

Results and Discussion
Our results consistently show the feasibility of isolating fixed and live tumor cells with a sensitivity close to one cancer cell per 10 mL of blood. We also demonstrate the feasibility of NGS analysis of single live cells enriched by ISET® with Ion Torrent Plateform. Our data provide evidence that the analysis of three single cells enriched by ISET® is sufficient to reliably identify the mutated allele frequency in the target cell population.

Conclusions
These technical improvements should help the study of circulating cancer cells at the early steps of tumor invasion.

Further information here: http://oncotrans.fr/

Columbia Univeristy, Herbert Irving Comprehensive Cancer Center – Attend the seminar of Prof. Paterlini-Bréchot, Scientific Advisor of Rarecells Diagnostics – December the 2nd, 2016 at 11:00 am

As invited speaker, Prof. Paterlini-Bréchot will give a special seminar at the Columbia Univeristy – Herbert Irving Comprehensive Cancer Center on December the 2nd, 2016 at 11:00 am entitled “Circulating tumor cells: a hallmark of invasion and window of the mechanisms of metastasis formation

4th Annual Advances in Prenatal Molecular Diagnostics Congress – Attend the Scientific Presentation of Prof Paterlini-Bréchot, Scientific Advisor of Rarecells Diagnostics – November the 29th, 2016 at 4:15 pm

As invited speaker, Prof Paterlini-Bréchot will attend the 4th Annual Advances in Prenatal Molecular Diagnostics Congress with a presentation on the 29th of November 2016 at 16:15 am entitled “Technical Insights into Highly Sensitive Isolation and Genetic Characterization of Trophoblastic Cells for Prenatal Non-Invasive Diagnostics of Genetic Disorders.”

Abstract:

Isolation of rare trophoblastic cells from blood or from cervix is a technical challenge with impact on the number of collected fetal cells and on the quality of their DNA. By using the ISET (Isolation by Size of Epithelial Tumor/Trophoblastic cells) system, we have developed different isolation protocols and analyzed the number of collected trophoblastic cells and the quality of their DNA at the single cell level. Our results show that ISET allows the consistent recovery of trophoblastic cells from blood and cervical samples and their complete genetic analysis. They also show that high throughput protocols can be developed aiming the use of trophoblastic cells collected non invasively for prenatal diagnosis of genetic disorders.

Further information here: http://www.healthtech.com/prenatal-diagnostics/

Forum Innovation & Assurance Santé – Attend the Lecture of Prof. Paterlini-Bréchot, CSO of Rarecells Diagnostics – 21 June 2016 at 14:15

As invited speaker, Prof. Paterlini-Bréchot will attende the session “KEYNOTES – LA PAROLE AUX INNOVATEURS DE LA SANTE !” with a lecture on June 2016, the 1st at 14:15 entitled “La femme qui fait reculer le cancer !

 

Further Information here: http://evenements.infopro-digital.com/argus/conference-innovation-medicale-et-sante-du-futur-2016-4452,programme